Study on absorption of hyaluronic acid after an oral administration in rats

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Study on absorption of hyaluronic acid after an oral administration in rats

JIANG Qiu-yan, LING Pei-xue, HUANG Si-ling, LIN Hong, ZHANG Tian-min(Division of Life Science and Technology, Ocean University of China, Qingdao 266003, China; School of Pharmacy, Shandong University, Jinan 250012, China)  

OBJECTIVE To study the absorption of hyaluronic acid (HA) administrated orally in rats.METHODS The concentrations of HA in rats serum were determined by the radioimmumoassay after a single dose of HA and three monosaccharides (D-glucuronic acid, N-acetylglucosamine and the equal mole ratio of both) were administered orally. The AUC was calculated by trapezoidal integration. RESULTS There were no evident changes with the serum HA levels in both of saline group and D-glucuronic acid group. The serum HA levels in HA group appeared an absorption peak at 2 h after an oral administration. The serum HA levels of other monosaccharides groups appeared a synthetic peak of HA at about 7 h after an oral administration. The main pharmacokinetic parameters of HA were as follows: AUC0-13 2 417 μg·h·L-1,ρmax 187.6 μg·L-1, tmax 2.0 h.CONCLUSION HA is absorbed and partial HA is absorbed as the form of non-monosaccharide after an oral administration.

出處：http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZGYX200523014.htm